Approach to IVF Treatment Failures: How to Plan your Next step?
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November 22, 2023

Approach to IVF Failures: How to Plan your Next step?

Experiencing an IVF failure can be heartbreaking, but it does not mean you cannot succeed in the future. The key is to understand what went wrong and plan wisely for the next step. This guide will help you understand why IVF may fail and what you can do next to improve your chances.

Step 1: Understanding Why IVF Failed

IVF failure can happen for many reasons. It is important to find out the possible cause so that you and your doctor can make the next attempt better.

1. Poor Embryo Quality

  • Not all embryos develop into healthy babies. Some embryos stop growing because they have genetic problems.
  • Solution: Preimplantation Genetic Testing (PGT) can check embryos for genetic issues before transfer.

2. Implantation Failure

  • Sometimes, the embryo does not attach properly to the uterus. This can happen due to:
    • A thin or weak uterine lining.
    • Uterine problems like fibroids, polyps, or scar tissue.
    • Immune system issues attacking the embryo.
  • Solution: Tests like Endometrial Receptivity Analysis (ERA) can check if your uterus is ready for implantation. Hysteroscopy can check for any physical issues inside the uterus.

3. Poor Egg Quality

  • Eggs from older women or those with certain medical conditions may have lower quality. Poor-quality eggs may not fertilize or grow properly.
  • Solution: A different medication plan, egg-boosting supplements (CoQ10, DHEA), or donor eggs can help.

4. Sperm Problems

  • If the sperm is weak, damaged, or low in number, it can affect fertilization and embryo development.
  • Solution: Advanced sperm selection techniques like ICSI, IMSI, or PICSI can improve sperm quality.

5. Hormonal Imbalance

  • Issues with thyroid, prolactin, or PCOS-related hormones can lower the chances of IVF success.
  • Solution: Blood tests can help balance hormone levels before another IVF attempt.

6. Poor Response to Ovarian Stimulation

  • Some women do not produce enough eggs during IVF stimulation.
  • Solution: A different medication protocol, using growth hormone, or a mild-stimulation IVF cycle may work better.

7. Problems During Embryo Transfer

  • If the embryo transfer is not done smoothly, the embryo may not implant properly.
  • Solution: A practice transfer (mock transfer) can help improve the technique for a successful embryo transfer.

Step 2: Reviewing the Failed IVF Cycle with Your Doctor

After an IVF failure, schedule a meeting with your doctor to discuss:

  • How many eggs were retrieved and their quality.
  • How well the embryos developed in the lab.
  • If the uterine lining was thick enough for implantation.
  • If the hormone levels were normal during the cycle.
  • If any additional tests are needed before another attempt.

By carefully reviewing these factors, you can plan a better strategy for the next cycle.

Step 3: Choosing the Next Approach

1. Try IVF Again with Changes

  • The doctor may suggest changing the medications, hormone levels, or timing to improve results.
  • Assisted Hatching (AH) may be used to help the embryo break out of its shell and implant better.

2. Use Preimplantation Genetic Testing (PGT)

  • PGT can check if the embryo has genetic problems before transfer, which can reduce miscarriage risks.

3. Consider a Frozen Embryo Transfer (FET)

  • Some doctors prefer transferring frozen embryos instead of fresh ones, as it allows the uterus to be more prepared.

4. Use Donor Eggs or Sperm

  • If egg or sperm quality is a major problem, using donor eggs or sperm can increase success rates.

5. Check the Uterus for Implantation Issues

  • Endometrial Receptivity Analysis (ERA) can help determine the best time for embryo transfer.
  • Hysteroscopy can check for fibroids, polyps, or scar tissue inside the uterus.

6. Make Lifestyle Changes

  • Eat a balanced diet rich in fruits, vegetables, and proteins.
  • Maintain a healthy weight (BMI between 18.5–25).
  • Avoid smoking, alcohol, and excessive caffeine.
  • Reduce stress through yoga, meditation, or therapy.

Step 4: Emotional & Financial Planning

Coping Emotionally After IVF Failure

  • It is normal to feel sad, frustrated, or even hopeless after an IVF failure.
  • Talking to a fertility counselor, joining a support group, or sharing your feelings with your partner can help.

Financial Planning for Another IVF Attempt

  • IVF can be expensive, so check for:
    • Clinic package deals or discounts for multiple cycles.
    • Insurance coverage options for fertility treatments.
    • EMI or loan options to manage costs.

Step 5: Deciding When to Try Again

  • Physical Recovery: Doctors recommend waiting for at least one or two menstrual cycles before trying again.
  • Emotional Readiness: Ensure you feel mentally prepared before starting another IVF cycle.
  • Medical Preparation: Complete any necessary tests and treatments to improve the chances of success.

IVF failure is tough, but it does not mean the end of your journey. By identifying the cause, making necessary changes, and preparing both physically and emotionally, you can increase your chances of success in the next attempt.

Key tips to deal with IVF Failures

Experiencing an IVF failure can be heartbreaking, but it’s important to stay hopeful and take the right steps to improve your chances in the next cycle. Here are some key tips to help you cope emotionally, physically, and medically after an unsuccessful IVF attempt.

1. Take Time to Process Your Emotions

IVF failure can bring feelings of sadness, frustration, or even guilt. It’s important to acknowledge your emotions and give yourself time to heal.

  • Talk to your partner, family, or close friends
  • Join a fertility support group to connect with others facing similar challenges.
  • Consider counseling or therapy if you feel overwhelmed.

2. Meet with Your Doctor for a Post-IVF Consultation

Understanding why IVF failed is key to improving your chances next time. Schedule an appointment with your doctor to discuss:

  • How your eggs and embryos developed.
  • Whether the uterine lining was receptive.
  • Any possible genetic issues with the embryos.
  • Changes that can be made for the next cycle.

Ask your doctor about additional tests like Endometrial Receptivity Analysis (ERA), Hysteroscopy, or Preimplantation Genetic Testing (PGT) if needed.

3. Focus on Lifestyle and Health Improvements

A healthy body improves fertility and increases IVF success rates. Make small but effective changes:

  • Eat a fertility-friendly diet – Include leafy greens, nuts, seeds, healthy fats, and lean protein.
  • Maintain a healthy weight – BMI between 18.5-25 is ideal for IVF.
  • Stay active – Moderate exercise like walking or yoga can improve blood flow.
  • Avoid smoking, alcohol, and excess caffeine – These can reduce fertility.
  •  Reduce stress – Practice meditation, acupuncture, or breathing exercises.

4. Consider Alternative IVF Approaches

If your first IVF attempt failed, your doctor may suggest modifying your approach:

  • Try a different ovarian stimulation protocol – Adjusting medications may improve egg quality.
  • Use frozen embryo transfer (FET) – A frozen cycle can improve implantation rates.
  • Consider embryo genetic testing (PGT-A) – To select the best-quality embryos.
  • Check for uterine issues – Hysteroscopy or saline sonography can identify fibroids or polyps.
  • Try donor eggs or sperm if necessary – This can help if egg or sperm quality is a major issue.

5. Give Yourself Time Before Trying Again

Most doctors recommend waiting at least 1-2 menstrual cycles before starting another IVF attempt. This allows:

  • Your body to recover from hormone treatments.
  • Your uterus to heal and be more receptive to implantation.
  • Time for emotional and financial planning.

6. Plan Financially for Future IVF Cycles

IVF can be expensive, so it’s helpful to explore:

  • Package deals or multiple-cycle discounts at your clinic.
  • EMI or financing options to manage costs.
  • Insurance plans that cover fertility treatments (if available).